At Prescott Center for Hormonal Balance, we provide personalized, results-driven treatment tailored to each patient’s unique needs. Bioidentical Hormone Replacement Therapy has the potential to transform lives. Discover how our patients have experienced meaningful change and improved well-being through our care.
Love the entire staff and how good they are. So professional and friendly!
Carol M.
Client
I appreciate the outstanding customer service I received by Brandi yesterday and that I always receive from the doctors at this wonderful practice! I highly recommend everyone here! Trust me, you won’t be disappointed with the outstanding care you will receive.
Susan Grabacki
Client
The best service. Always a pleasure going to an appointment. You never feel rushed.
Stephanie H.
Client
The providers in this office give clear and detailed information for patients to make educated decisions. The services I have received have changed my life!! I’m a happy 68-year-old woman!
Katie L.
Client
Very pleasant and efficient. Brandi is a jewel and along with Dr. J. Waara, they make a great team. I feel very comfortable with Dr. Waara and I talk to her about everything going on with my body. I never have to wait for my appointment. A very efficient team!
C. Draper
Client
I absolutely love Dr. Waara and Dr. Darr. Good hometown feel and the nicest people around. Brandi is pretty special too!
Kandice B.
Client
Stay informed with the latest updates, expert insights, and evidence-based articles on Bioidentical Hormone Replacement Therapy (BHRT). From breakthrough research and clinical advancements to wellness tips, our curated content helps you explore the evolving world of hormone health. Whether you’re just beginning your journey or seeking in-depth information, our articles are designed to support your well-being and decision-making every step of the way.
by Catherine J. Rourke
Featured in Medical Daily: https://www.medicaldaily.com/bioidenticalpellet-therapy-safe-solution-menopausal-symptoms-473698
Millions of women in the US remain untreated for debilitating menopausal symptoms, according to a recent report from the AARP Public Policy Institute. While over 2 million women enter menopause annually, an estimated 8 to 10 million women experience severe symptoms for seven years or more due to the loss of estrogen, affecting their quality of life.
Yet confusion and misinformation about menopause treatments still persist, preventing access to hormone replacement therapy (HRT). As a result, the AARP findings suggest that only a small percentage of women who could benefit from effective menopause treatments are receiving them.
This report mirrors dozens of others documenting women’s increased mortality rates due to the hormone conundrum.
A 2013 study indicated that “over 50,000 women may have lost their lives due to inaccessibility of the estrogen replacement their bodies needed.” Additional studies from 2013 to 2024 have also documented the mortality toll of estrogen avoidance.
Emphasizing a growing concern over these setbacks, the Society for Women’s Health Research (SWHR) website states:
“There is a pressing need to develop more effective treatment options to manage challenging menopausal symptoms and increase awareness about the health impacts associated with menopause including cardiovascular disease, osteoporosis, and diabetes – among women, health care providers, and society at large.”
The SWHR urges medical practitioners, employers, and policy leaders to:
One visionary industry leader is already answering that clarion call and trailblazing the way forward.
CarolAnn Tutera, CEO and president of Tutera® Medical/SottoPelle®, addressed these issues over 30 years ago when she and her late husband, Gino Tutera, MD, began treating patients for menopause using natural bioidentical hormone pellet therapy. Backed by 85 years of scientific research, their groundbreaking developments and innovative dosing method paved the way for pellet practices globally.
As the first woman who launched an entire industry bringing this therapy to the forefront, CarolAnn is the reason it is practiced today. “Hormones serve as the control panel for every organ and function of the body and brain,” she said. “Subcutaneous bioidentical pellets are the safest and most effective form of HRT available.”
The SottoPelle Method® uses plant-based bioidentical hormone pellets that match the molecular structure of human hormones. Gently slipped under the skin, pellets provide 24-7 delivery for optimal effectiveness and typically last four to six months.
CarolAnn notes that the medical industry often fails to distinguish synthetic pharmaceutical hormones from the natural bioidentical kind. And therein lies the cause of the hormone debacle.
“This misunderstanding poses a deterrent to safe approaches,” she said. “Many providers are convinced that all estrogen is dangerous because they’re only aware of pharmacological forms that can trigger harmful side effects.”
Always ahead of her time, CarolAnn remains a trailblazer in the role hormones serve in brain and mental health. Her company has been using pellet therapy to treat neurodegenerative diseases since 2013. Since estrogen regulates cognitive function, she correlates it with the spike of Alzheimer’s and dementia in menopausal women. She is now collaborating with other researchers on studies showing the impact of pellet therapy on brain function.
Identifying safe, effective treatments can eliminate barriers preventing women from accessing care that may help prevent major disease. CarolAnn continues her passionate commitment to make pellet therapy available to women and men so everyone can stay healthy and age gracefully.
by Catherine J. Rourke
As seen in Maxim, Oct. 14, 2024
Testosterone fuels the brain, influencing the neurotransmitters regulating your memory, mood, motor control, behavior and cognitive functions. Research indicates it has been used to treat osteoporosis, metabolic syndrome and cholesterol. T therapy may help prevent Alzheimer’s and other neurodegenerative diseases.
As SottoPelle’s CEO, CarolAnn Tutera is the original female industry leader, continuing what she and Dr. Tutera started in the 1990s. “We’re working with ex-NFL players and veterans and excited about the progress they’re making,” she said. “We support everyone on their journey and have so many success stories.”
Advances in TRT therapy show it’s helping men stay sharp, strong and energized. A 2023 Harvard Health study cites the cardiovascular safety of TRT in preventing strokes and heart attacks. A recent meta-analysis of 35 clinical studies found TRT restored normal T levels to enhance men’s strength, brainpower and vitality without cardiovascular risks.
SottoPelle is committed to helping athletes, veterans, and anyone with head injuries or low T to regain their muscle and mojo.
The stress of modern life can take its toll on men, triggering low T levels that impact their health and life expectancy.
Current medical data shows T levels dropping at younger ages. A 2021 report found that the average T level in men ages 15-39 has plummeted by 25 percent. The American Urological Association guidelines and additional studies have concluded that:
According to Dr. Tutera, “Hormones are the control panel for every organ and function of the body and brain. By age 50, most men have lost over half of their testosterone, disrupting their physiological and neurological processes.”
If left untreated, low T can lead to cognitive decline, weight gain, high cholesterol, fatigue, irritability, heart disease, prostate issues, diabetes, depression and the loss of muscle, bone, stamina and libido.
A June 2024 report highlighting 11 studies on 24,000 men attributes low T to the spike in strokes and a 60 percent higher risk of cardiovascular mortality than men with normal T levels. This echoes dozens of studies showing the correlation between low T, heart disease and lower longevity.
But how do you know if you’re low? A simple blood test is all you need. SottoPelle has helped thousands of worldwide providers trained in the same effective method McMahon uses to get back on track and stay there.
Boosting your T will rev up your motor and help you get your mojo back. But it does so much more than just build biceps. Patients report a reduction in cholesterol, insulin resistance, visceral fat and plaque in the coronary arteries. How does it work? Think of it like TNT for your body and brain. But not all forms of T are alike.
Synthetic or pharmaceutical hormones in pills, patches, gels, creams and troches are poorly absorbed and deliver T in fluctuating surges. Since they’re foreign to your body, side effects can occur.
Bioidentical hormones, similar in molecular structure to your natural T, can penetrate the cells regulating your physical and mental functions without adverse reactions. Numerous reports attest to the safety of these natural, plant-based hormones.
According to Dr. Tutera, using synthetic testosterone is like pouring high-grade oil on a cracked engine. “The car still won’t run,” he said. “When prescribed, dosed and administered correctly, bioidentical testosterone can rebuild that cracked engine so it will start up again.”
by Catherine J. Rourke
As seen in USA Today, Aug. 24, 2023
Neurobiology may sound complex, but boosting your brainpower is simple with SottoPelle® science.
“While this represents time-revered endocrinology and isn’t rocket science,” said Tutera, “BHRT offers a solution backed by studies in the prevention of serious maladies to offset the development of major diseases.”
According to Dr. Tutera, “This is the only safe, effective approach to eliminating the root of all disease and physical dysfunction by restoring hormonal balance, normal neurotransmitter processes and normal physiology of the body. It’s the best preventative antidote in modern medicine to alleviate the devastating illnesses and often fatal diseases caused by stress.”
As pioneers bringing pellet therapy back into the mainstream with precision dosing, SottoPelle® paved the way decades ago as the visionary industry leader for pellet practices across America.
Today, Dr. Tutera’s wife CarolAnn continues his legacy as president of SottoPelle®, now celebrating 30 years helping more than 250,000 patients worldwide enjoy happier, healthier lives.
Pioneering physician Dr. Gino Tutera MD, FACOG, an expert in neurodegenerative disorders, described the best approach for health and happiness in his books and presentations as “an inside job.” Maintaining the intricate biochemical balance for optimal well-being and disease prevention formed the heart of his 40-year practice dedicated to restoring the physical, mental and emotional vitality of his patients.
Internationally recognized as the foremost leader in bioidentical hormone replacement therapy (BHRT), Dr. Tutera developed the SottoPelle® Method in 1992. A natural plant-based hormone replacement based on his proprietary bioidentical pellet delivery system, the SottoPelle® Method uses the multi-patented Dosaggio™ dosing site to restore normal physiologic balance.
Speaking on hormones, Dr. Tutera asserted that “Everyone doesn’t wear the same shoe size, so why would they wear the same hormone dose? Think of hormones like the shocks in a car. You can plan on a bumpy ride if they’re worn out.”
As patients reported smoother rides and significant improvements in their vitality, Dr. Tutera observed another remarkable result. Their blues were melting away, along with brain fog, mood swings, memory loss and insomnia. He established a direct link between natural hormone balance, happiness and healing of the mind, body and spirit.
Human health declines despite medical advances
According to Johns Hopkins Medicine data, more than 9.5 percent of U.S. adults 18 and over suffer from depression. The National Institute of Mental Health reveals that 21 million adults experience depression, with the highest episodes among ages 18-25. Studies also indicate that cognitive decline and neurodegenerative conditions now start at earlier ages.
A 2023 Alzheimer’s Association report states that two-thirds of the 6.7 million Americans diagnosed with Alzheimer’s dementia are women.
Dr. Tutera focused extensively on brain health. His groundbreaking research explored the treatment of dementia, depression, Alzheimer’s, Parkinson’s disease, Traumatic Brain Injury and other neurodegenerative conditions.
By ,
As seen in CNN November 10th, 2025
In a pivotal move, the US Food and Drug Administration said Monday that it is taking steps to remove the lengthy “black box” warning on many hormone treatments for women with menopause symptoms, a shift expected to give women more options for treatment and generate a flood of new prescriptions. Hormone therapy has long been on the market, but prescriptions plummeted after 2003, when the warning described increased risks of cardiovascular disease, stroke, breast cancer and dementia.
“After 23 years of dogma, the FDA today is announcing that we are going to stop the fear machine steering women away from this life-changing, even life-saving, treatment,” FDA Commissioner Dr. Marty Makary said in announcing the change. Prescribing requires nuance, FDA officials said, especially around when women start hormone therapy. Some women still face some risks from hormone therapy, including those at increased risk of blood clots or who have previously had breast cancer. But for many women, the benefits may far outweigh the risks.
“With the exception of vaccines or antibiotics, there’s no medication that can improve the health of women on a population level more than hormone replacement therapy,” Makary posted on X Monday morning.
It could take months for the labels to change, but drugmakers are “very excited” to make the update, Makary said. Label changes will include updated guidance that hormones should be initiated in women who are younger than 60 or within 10 years of menopause to optimize benefits and risks, and removal of guidance to use the lowest effective dose for the shortest amount of time — clearing the way for women to stay on the treatments for years.
“We want people to talk to their doctors, and we want doctors to have the right information, and part of that means removing these scary black box warnings and putting the nuanced discussion in the package insert of the medications,” Makary said.
Women’s health experts praised the move to update the boxed warning to reflect newer scientific evidence around menopausal hormone therapy but said individualized discussions of risks and benefits will still be needed. Dr. JoAnn Manson, chief of preventive medicine at Brigham and Women’s Hospital and a past president of the Menopause Society, said the labeling change was overdue.
“Right now, this box warning is a one-size-fits-all summary that hormone therapy increases the risk of all these conditions,” Manson said. “It doesn’t take into account whether it’s local estrogen or systemic estrogen, the age of the woman, the type of the formulation.”
Dr. JoAnn Pinkerton, a professor of obstetrics and gynecology at the University of Virginia School of Medicine, said she is among many doctors who advocated for label changes for years.
“Removing the scary boxed warning from local vaginal estrogen is a victory for women’s health and for those who care for and about menopausal women,” Pinkerton said in a statement. “Regarding the removal of the boxed warning for systemic hormone therapy, which is absorbed into the bloodstream and has systemic effects throughout the body, we appreciate the FDA’s thoughtful, nuanced approach. Discussions will be more complicated and need to be individualized, as different menopause therapies differ in potential risks.”
The black box warning is the strongest type of alert the FDA puts on a drug label. Since 2003, labels of menopause treatments that contain estrogen – including pills, patches, sprays and creams – have warned that their use can increase the risk of uterine and breast cancers, as well as strokes and blood clots. The labels also warned about an increased risk of dementia for women over the age of 65.
The black box warning, or boxed warning, was added after a large government-funded study, the Women’s Health Initiative, found in 2002 that women taking estrogen pills after menopause had some higher health risks compared with women who took a placebo. The study participants had an average age of 63, so many were past menopause when they started the therapy.
After the study and the label change, doctors became reluctant to prescribe them, and prescriptions for hormone therapy for menopause dropped by more than 70%. In the late 1990s, more than 1 in 4 postmenopausal women were taking hormones to manage symptoms such as hot flashes, mood swings and night sweats. By 2020, that number had dropped to about 1 in 25, one study found.
“It’s been a total horrible tragedy that so many millions of women have been deprived,” said Dr. Erika Schwartz, a New York-based internist and author of the books “Don’t Let Your Doctor Kill You” and “The New Hormone Solution.”
“Hormone therapy is important because for about 10 to 15 years before you go into menopause, your hormones start leaving you. As your hormones start leaving you, you need more hormones. And you don’t need hormone replacement; you need hormone supplementation,” Schwartz said.
“Chronic illnesses like heart disease, Alzheimer’s, osteoporosis, cancer, they are diseases of aging, and one reason is the loss of hormones.”
More recent analyses of the Women’s Health Initiative, as early as 2010, have since shown that hormone therapy started in women younger than 60, or within 10 years of starting menopause, can more safely help manage menopausal symptoms such as hot flashes and poor sleep as long as the women don’t have specific contraindications such as a history of hormone-sensitive breast or uterine cancer.
Edited by Devyani Gholap
Medscape News UK © October 9, 2025
Men with diabetes and hypogonadism who received testosterone therapy had lower risks for acute kidney injury, kidney failure requiring replacement therapy, cardiovascular events, and all-cause mortality than those who did not receive the treatment.
“[The study] findings suggest that testosterone therapy could be more readily considered for men with diabetes and hypogonadism as a potential intervention to prevent kidney injury,” the authors of the study wrote.
This study was led by Fabrice Bonnet, Service Endocrinologie-Diabétologie CHU de Rennes, Université de Rennes, Rennes, France. It was published online on October 01, 2025, in Cardiovascular Diabetology.
